In his second epistle to Timothy, Paul writes: “Just as Jannes and Jambres opposed Moses, so these men also oppose the truth, men corrupted in mind and disqualified regarding the faith.” (2 Tim. 3:8). The names “Jannes and Jambres” are not listed in Exodus. Since they are connected with the false teachers Paul discusses in 2 Timothy 3, their mention raises a number of questions. Who were Jannes and Jambres? What exactly did they do in opposing Moses? The discovery of The Apocryphon of Jannes and Jambres leads one to ask, did Paul accept this document as Scripture? This paper will endeavor to explore these issues.